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September 26, 2018 By opticiancertif

Leber hereditary optic neuropathy (LHON)

A disease entity that most commonly affects young men in their teens and early twenties and causes significantly decreased central vision in both eyes. The genes that cause LHON are carried on small circular mitochondrial DNA molecules that are inherited from an individuals mother. This condition is extremely rare (affecting fewer than 1 per million people per year) and does not affect everyone who harbors the genetic defect. The visual field defects in LHON are typically cecocentral scotomas. There are three other eye diseases named after Theodore Leber: 1) Leber congenital amaurosis (blindness at birth) inherited in an autosomal recessive fashion, 2) Leber’s stellate neuroretinopathy (a non-heritable condition associated with cat scratch disease) and 3) Leber’s military aneurysms (a non-heritable vascular malformation of the retina similar to Coat’s disease).

Related Links

Leber hereditary optic neuropathy – Genetics Home Reference – NIH

Leber Hereditary Optic Neuropathy (LHON)

Leber’s hereditary optic neuropathy

Leber Hereditary Optic Neuropathy. Causes and diagnosis — ICR

[Full text] Leber hereditary optic neuropathy: current perspectives — OPTH

Continuing Education

Leber’s Hereditary Optic Neuropathy: Causes, Symptoms, Treatment — Santhera Switzerland

Prophylaxis for Second Eye Involvement in Leber Hereditary Optic Neuropathy: An Open-Labeled, Nonrandomized Multicenter Trial of Topical Brimonidine Purite

Mitochondrial replacement in an iPSC model of Leber Hereditary Optic Neuropathy. — bioRxiv

Bilateral vision loss due to Leber?s hereditary optic neuropathy after long-term alcohol, nicotine and drug abuse — SpringerLink

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Leber's Hereditary Optic Neuropathy

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    Leber's Hereditary Optic Neuropathy

    View More
  • <
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    Patient Story - Leber's Hereditary Optic Neuropathy

    View More
  • <
    >

    Alfredo Sadun MD PhD - Leber's Hereditary Optic Neuropathy: New Treatments and Trials

    View More
  • <
    >

    LHON Stem Cell Patients Michelle and Nicholas

    View More
  • <
    >

    LHON Infographic

    View More
  • <
    >

    Optic Neuropathy Part 2: Ischemic Compressive Hereditary

    View More
  • <
    >

    LHON - Living with Blindness

    View More
  • <
    >

    Genetic Metabolic Basis of LHON - Doug Wallace PhD

    View More
  • <
    >

    Leber's Hereditary Optic Neuropathy on AM Minnesota April 18 2016

    View More
  • <
    >

    GenSight

    View More
  • <
    >

    Non-Vision Symptoms and LHON - Dr Amel Karaa

    View More
  • <
    >

    LHON Documentary

    View More
  • <
    >

    New Vision Update After Having Stem Cell Treatment To Treat Optic Atrophy ? What Am I Seeing Now

    View More
  • <
    >

    Leber's hereditary optic neuropathy (Medical Condition)

    View More
  • <
    >

    Living With Blindness: LHON Q A

    View More

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